Friday 6 November
PLENARY SESSION
08:30-10:00
Audit. Saint-Exupéry - Level 2SESSION 4 - Tumor immunity
Chairs: Bruno SILVA-SANTOS (Lisbon, Portugal) & Fabienne HASPOT (Nantes, france)
- Bruno SILVA-SANTOS (Gulbenkian Institute for Molecular Medicine (GIMM), Lisbon, Portugal)
Harnessing gamma-delta T cells against cancer - Marisol SOENGAS (Melanoma Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain)
+ Selected short oral presentations
- P4-01 - YLan BLANCHARD (Centre de Recherches en Cancérologie de Toulouse (CRCT), Toulouse, France)
Role of intestinal CD8 T cells in the control of colorectal cancer metastases - P4-02 - Alexandre LANAU (U1330 - Children's Oncology Research Unit, Institut Curie, Paris, France)
“Nature vs Nurture” : Understanding How TCR-pMHC history shapes T cell fate during polyclonal response in solid tumors - P4-03 - Yenkel GRINBERG-BLEYER (Cancer Research Center of Lyon, Lyon, France)
NF-kappaB transcription factor c-Rel governs CD8+ T-cell function in cancer
10:00-10:45
Foyer & Concorde 1&2 - Level -1Coffee break - Visit of exhibition & Posters
PARALLEL SESSIONS
10:45-12:15
PS23 - Immunotherapy
Chairs: Michel COGNÉ (Rennes, France) & Nicolas FAZILLEAU (Toulouse, France)
- Karin TARTE (Inserm, Unité Mixte de Recherche U1236, Université Rennes, EFS, Rennes, France)
- Bruno SEGUI (INSERM UMR 1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France)
TNF blockade with certolizumab improves the efficacy of anti-PD-1 and anti-CTLA-4 combination therapy for melanoma
+ Selected short oral presentations
- PS23-01 - Caroline PLAZY (Department of Biochemistry, Molecular Biology, Grenoble-Alpes University Hospital, Grenoble, France)
Circulating Metabolites Link Gut Microbiota Composition to Clinical Outcomes under Immune Checkpoint Inhibitors in NSCLC - PS23-02 - Samad MOHAMMADNEZHADDARYANI (U981, Gustave Roussy, Villejuif, France)
eIF4F targeting rewires T cell exhaustion and overcomes immunotherapy resistance - PS23-03 - Alex PRIGENT (Endothelial Cells in Immunity, Inflammation and Cancer, IPBS, CNRS, TOULOUSE, France)
High endothelial venules mediate B cell entry into tumors and tertiary lymphoid structures during PD-1 plus CTLA-4 immunotherapy
10:45-12:15
PS24 - Glycoimmunology
Chairs: Salomé PINHO (Porto, Portugal) & Anne ASTIER (Toulouse, France)
- Salomé PINHO (i3S - University of Porto, Porto, Portugal)
Turning Sweet in Immunity: glycans as master regulators of immune response in chronic inflammation, autoimmunity and cancer - Heinz LAUBLI (University of Basel, Basel, Switzerland)
Local glycan engineering induces systemic antitumor immune reactions via antigen cross-presentation
+ Selected short oral presentations
- PS24-01 - Yoann ROMBOUTS (Univ Toulouse, CNRS, IPBS, Toulouse, France)
Polysialylation governs inflammatory monocyte egress from the bone marrow - PS24-02 - Beatriz SANTOS-PEREIRA (Institute for Research and Innovation in Health (i3S), Porto, Portugal)
Complex branched glycosylation as a key regulator of type-3/γδT17 response associated with autoimmunity - PS24-03 - Léna ANDRIEUX (INFINITy, INSERM UMR1291, Toulouse, France)
Role of IgE glycosylation in allergic diseases
10:45-12:15
PS25 - Tolerance and Transplantation
Chairs: Meryem ALOULOU (Toulouse, France) & Mathieu CHEVALLIER (Marseille, France)
- Carole GUILLONNEAU (Nantes Université, CHU Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, Nantes, France)
- Julien ZUBER (Université Paris Cité, INSERM U1151, CNRS 8253, Institut Necker Enfants Malades, Paris, France)
+ Selected short oral presentations
- PS25-01 - Mael SEITE (Mononuclear phagocytes, Immunopathology, Immunovirology, Center for Research in Transplantation and Translational Immunology, Nantes, France)
Autologous Tolerogenic Dendritic Cells Promote Treg Induction through Lactate Secretion - PS25-02 - Sahil ADRIOUCH (University Rouen Normandie, INSERM, Normandie University, Rouen, France)
Nanoparticles targeting liver sinusoidal endothelial cells improve AAV gene transfer and promote tolerance-spreading to capsid and transgene epitopes - PS25-03 - Alice KOENIG (INSERM U 1111, Lyon, FRANCE)
IRE1α-XBP1 inhibitors: a promising approach to treat chronic vascular rejection after organ transplantation
PLENARY SESSION
12:15-13:15
Audit. Saint-Exupéry - Level 2SFI General Assembly
13:15-14:15
Foyer & Concorde 1&2 - Level -1Lunch - Coffee - Visit of exhibition & Posters
PARALLEL SESSIONS
14:15-15:45
PS26 - Environmental cues and microbiota
Chairs: Dalil HANNANI (Grenoble, France) & Julie RIBOT (Lisbon, Portugal)
- Thomas GENSOLLEN (Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, Toulouse, France)
Early-life imprinting by the microbiota orchestrate persistent mucosal homeostasis - Ilana GABANYI (Gulbenkian Institute for Molecular Medicine (GIMM), Lisbon, Portugal)
Neuronal responses to bacterial signals: the influence of sex hormones
+ Selected short oral presentations
- PS26-01 - Fikir ASFAW (Gulbenkian Institute for Molecular Medicine (GIMM), Lisboa, Portugal)
IL-17 regulates peripheral nerve regeneration in a microbiota dependent manner - PS26-02 - Rodrigo DE OLIVEIRA FORMIGA (CRSA, Inserm U938, Sorbonne Université, Paris, France)
Gut Microbiota Regulates Host Immune Bioenergetics - Role of Proline Metabolism In Monocytes Phenotype - PS26-03 - Nicolas BOULADOUX (Department of Immunology / Metaorganism Unit, Institut Pasteur, Paris, France)
Deciphering the crosstalk between skin commensals and the immune system
14:15-15:45
PS27 - System and spatial immunology
Chairs: Nicolas FAZILLEAU (Toulouse, France) & Luis GRACA (Lisbon, Portugal)
- Luis GRACA (Gulbenkian Institute for Molecular Medicine (GIMM), Lisbon, Portugal)
Regulation of humoral responses in health and disease - Vera PANCALDI (INSERM UMR 1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France)
+ Selected short oral presentations
- PS27-01 - Fanny LAFOURESSE (UMR1037 Inserm - UMR 5071 CNRS - Université de Toulouse, CRCT, Toulouse, France)
Spatial characterization of CD8⁺ TRM heterogeneity within B-cell aggregates and tertiary lymphoid structures in triple-negative breast cancer - PS27-02 - Miguel MENDES FERREIRA (Department of Pathology, Leiden University Medical Center (LUMC), Leiden, Netherlands)
Single cell spatial profiling of immune contextures in MMRd colorectal cancer reveals distinct microenvironments associated with HLA-class-I loss - PS27-03 - Keerthi KURMA (Laboratoire Cellules Circulantes Rares Humaines, Centre Hospitalier Universitaire de Montpellier, Montpellier, France)
Liquid biopsy reveals the immune status and protein profiles linked to CTC burden and clinical outcomes in metastatic breast cancer
14:15-15:45
PS28 - Antibody
Chairs: Guy GOROCHOV (Paris, France) & Maria DEL MAR NARANJO GOMEZ (Montpellier, France)
- João GONÇALVES (Faculdade de Farmácia da Universidade de Lisboa, Lisbon, Portugal)
- Nadia DUARTE (Instituto de Biologia Experimental e Tecnológica (iBET), Oeiras, Portugal)
Generation of versatile tumour target cell lines using the SpyCatcher/SpyTag system to evaluate antibody-based immunotherapies
+ Selected short oral presentations
- PS28-01 - Stella ROUSSET (IPBS, CNRS / University of Toulouse, Toulouse, France)
Targeting the C-type lectin receptor DCIR using synthetic single-domain antibodies: a promising strategy for immune modulation in tuberculosis and beyond - PS28-02 - Stéphane PINHAL (Bruker Dynamic Biosensors, München, Germany)
Integrated Biophysical Analysis of Fc–FcR Binding, Affinity, and Avidity in Antibody Therapeutics - PS28-03 - Antoine PRAITÉ (CRIBL laboratory - UMR CNRS7276 - INSERM U1262, Limoges, France)
A comprehensive, transcriptome-wide overview of post-transcriptional control of plasma cell differentiation
PLENARY SESSIONS
15:45-16:30
Audit. Saint-Exupéry - Level 2Closing Keynote Lecture
Chairs: Nicolas FAZILLEAU (Toulouse, France)
- Pamela SCHWARTZBERG (Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA)
16:30-17:00