SFI 2025

PLENARY SESSIONS

Amphi. Gaston Berger - Level S2SESSION 4 - Innate/intrinsic immunity

Chairs: Kamel BENLAGHA (Paris, France) & Tom LE VOYER (Paris, France)

• Étienne PATIN (Human Evolutionary Genetics, Pasteur Institute, Paris, France)
  The environmental and evolutionary drivers of human immune variation
• Estibaliz LAZARO (Origins and pathogenesis of autoimmune and inflammatory disorders, ImmunoConcEpT, Bordeaux, France)
  Is Chronic Histiocytic Intervillositis an Auto-Inflammatory Disease?

Selected short oral presentations

• P4-10 - Cian REID (Human Evolutionary Genetics, Institut Pasteur, Paris, France)
  Deconvoluting the genetic basis of innate immune variation in a healthy European population
• P4-11 - Fanny ONODI (U1342, Team ATIP Avenir, P. Tonnerre, IRSL, Paris, France)
  DC3 cells coordinate cytokine responses and virus-specific T cell activation in response to influenza
• P4-12 - Alexis BROQUET (INSERM UMR1064 CR2TI, Nantes Université, Nantes, France)
  Sepsis-trained lung signature segregates IL-17+ resident Vg6 gdT cells in specialized adventitial cuffs regions. Impact on anti-tumoral response in the lungs

Amphi. Gaston Berger - Level S2Industry Symposia

Chair: Kamel BENLAGHA (Paris, France)

• Beckman Coulter
  Alban GERVAIS (Beckman Coulter Life Sciences)
  Introducing CytoFLEX mosaic. Spectral flow cytometry meets modularity

• Stemcell Technologies
  Pegah SEDDIGH (STEMCELL Technologies)
  Streamline tissue processing using the new, automated STEMprep™ Tissue Dissociator

• Cytek Biosciences
  Fabien PITOISET (Cytek Biosciences)
  Evolutions of the Cytek® Full Spectrum Profiling™ (FSP®) Flow Cytometry Solutions

Foyers - Levels S1-S2-S3Coffee break - Visit of exhibition - Posters

PARALLEL SESSIONS

Salle Louis Armand Ouest - Level S3SP18 - Microbiota in health and disease

Chairs: Dalil HANNANI (Grenoble, France) & Delphine SCALBERT-STERLIN (Paris, France)

• Harry SOKOL (Microbiota, intestine and inflammation, Research Center Saint-Antoine, Paris, France)
  Gut microbiota in IBD: from observation to therapeutic intervention
• David BIKARD (Synthetic biology, Pasteur Institute, Paris, France)
  In situ genetic perturbation of bacteria in the mouse gut

Selected short oral presentations

• SP18-46 - Anna LLEBARIA FABRIAS (Institut Cochin, Paris, France)
  IL4I1 induces gut and skin dysbiosis promoting melanoma development: modulating skin microbiota to restore anti-tumoral responses
• SP18-47 - Rémy VILLETTE (Systems Ecology, Luxembourg Centre for Systems Biomedicine, Esch sur Alzette, Luxembourg)
  Integrated multi-omics of the gut microbiome in Parkinson’s disease reveals a functional disruption of bacterial motility and cross-feeding
• SP18-48 - Elise DHILLY (Inserm UMR-S1135 - Centre d'Immunologie et des maladies infectieuses (CIMI), Sorbonne Universite, Paris, France)
  Humoral immunity to maternal and infant gut microbiota during pregnancy and early life

Salle Louis Armand Est - Level S3SP19 - Gene and Cell therapy

Chairs: Jacques NUNÈS (Marseille, France) & Nathalie CHAPUT (Villejuif, France)

• Anne GALY (Accelerator of Technological Research in Genomic Therapy, INSERM, Corbeil-Essonnes, France)
  Recent advances and remaining challenges in lentiviral transduction and gene editing of lymphocytes and hematopoietic stem cells
• Jean-Luc PERFETTINI (Molecular radiotherapy and therapeutic innovations, Gustave Roussy Institute, Villejuif, France)
  Next-generation phagocytosis-guided myeloid cell immunotherapy for cancer treatment

Selected short oral presentations

• SP19-49 - Janie ROBERT (i3 laboratory (Immunology-Immunopathology-Immunotherapy), Sorbonne University - UMRS959, Paris, France)
  Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficacy in mouse autoimmune models
• SP19-50 - Mattia FUMAGALLI (Cancer immunotherapy and cell reprogramming, Equipe Bercovici-Blondel, Institut Cochin, Paris, France)
  An in vivo CRISPR screen unveils top target genes to improve CAR-T cell efficacy in a solid tumor model
• SP19-51 - Manon LUCAS (TaRGeT UMR1089 -Nantes Université, Nantes, France)
  High systemic dosing of rAAV9 vectors: a relevant rat model to study the impact of immunoregulation in the liver

Amphi. Gaston Berger - Level S2SP20 - Imaging the immune system

Chairs: Mathieu CHEVALIER (Paris, France) & Thibaut NANINCK (Paris, France)

• Alessandro FURLAN (CANTHER laboratory, Institut ONCOLille, University of Lille, France)
  Imaging tumors-on-chips as pre-clinical models mimicking the tumor microenvironment
• Thibaut NANINCK (IDMIT - Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases, CEA, Fontenay-aux-Roses)
  Whole-body in vivo imaging of pathogens and immune responses in NHP models of human infectious or auto-immune diseases

Selected short oral presentations

• SP20-52 - Eléonore BETTACCHIOLI (CHU de Brest, Brest, France)
  Spatial Immune Diversity in Lupus Nephritis Across Kidney Architecture and Histological Classes
• SP20-53 - Grégoire MÉNARD (CR2TI, INSERM, Nantes, France)
  Spatial Immune Profiling Reveals Distinct Landscapes in TCMR and Mixed Rejection after Pediatric Kidney Transplantation
• SP20-54 - Céline RAGUÉNÈS-NICOL (Irset - UMR_S 1085, Univ. Rennes, INSERM, EHESP, Rennes, France)
  Multiplex immunofluorescence imaging of the immune microenvironment of hepatocellular carcinoma associated with metabolic and alcohol related liver disease

PLENARY SESSION

Amphi. Gaston Berger - Level S2SFI General Assembly

Foyers - Levels S1-S2-S3 Lunch - Coffee - Visit of exhibition & Posters

PARALLEL SESSIONS

Salle Louis Armand Ouest - Level S3SP21 - Antibodies Club

Chairs: Delphine SCALBERT-STERLIN (Paris, France) & Guy GOROCHOV (Paris, France)

• Matthieu MAHEVAS (Autoimmune and B cells immune response, Necker Hospital for Sick Children, Paris, France)
  Title upcoming
• Salomé PINHO (i3S, Porto, Portugal)
  Changes in the glycosylation of circulating IgG predict future Crohn's Disease onset: impact in disease immunopathogenesis

Selected short oral presentations

• SP21-55 - Edouard LEVEQUE (Asthme, Allergie et Immunothérapie, Institut Toulousain des Maladies Infectieuses et Inflammatoires, Toulouse, France)
  Development of a fully human anti-SARS-Cov2 broadly neutralizing mAb using tonsil organoids
• SP21-56 - Martin JUNGBAUER-GROZNICA (Antiviral Activities of Antibodies Group, Institut Pasteur, Université Paris Cité, CNRS UMR3569, Paris, France)
  Complement Mitigates Neutralization Resistance of SARS-CoV-2 Variants
• SP21-57 - Sarah MARCHAND (Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes Université, INSERM, Nantes, France)
  BKPyV B cell repertoire analysis and broadly neutralizing antibody identification in kidney transplant recipients

Amphi. Gaston Berger - Level S2SP22 - Immunotherapy Club

Chairs: Makoto MIYARA (Paris, France) & Jacques NUNÈS (Marseille, France)

• Ricardo GRIESHABER-BOUYER (University Hospital Erlangen, Germany)
  CAR T cell therapy and T cell engager therapy to reset the B cell compartment in autoimmune disease
• Monica CASUCCI (San Raffaele Research Institute, Milan, Italy)
  Advancing CAR-T therapy in solid tumors: a novel product for CRC and glycosylation blockade to enhance efficacy

Selected short oral presentations

• SP22-58 - Audrey MERIENNE (UMR 1302 Inserm, Immunology and New Concepts in ImmunoTherapy (INCIT), Nantes, France)
  Efficient killing of TAP1-deficient colorectal cancer cells by infiltrating tumor CD8 T lymphocytes: a promising immunotherapy target
• SP22-59 - Grégoire STYM-POPPER (Eq. You / Mallone, INSERM U1016 - Institut Cochin, Paris, France)
  Therapeutic potential of anti-CD3 and Fc-fused preproinsulin as a combined intranasal immunotherapy for type I diabetes prevention in a pre-clinical mouse model
• SP22-60 - Camille ROLIN (Department of Infection and Immunity, Luxembourg Institute of Health, Esch-Sur-Alzette, Luxembourg)
  Strength in unity: a dual strategy to restore NK cell cytotoxicity against pancreatic ductal adenocarcinoma

Salle Louis Armand Est - Level S3SP23 - NK-ILCs Club

Chairs: Emilie NARNI-MANCINELLI (Marseille, France) & Sébastien VIEL (Lyon)

• Éric VIVIER (Innate lymphoid cells, CIML, Marseille, France)
  On NK cells and other ILCs

Selected short oral presentations

• SP23-61 - Rayan EL-KHOLDI (Sanofi Research and Development, Sanofi, Vitry-sur-Seine, France)
  Unraveling the spatial distribution and interactions of NK cell subsets in non-small cell lung cancer tumor using spatial transcriptomics
• SP23-62 - Oscar HAIGH (IMVA-HB/IDMIT/UMR1184 - LIT, Université Paris-Saclay, INSERM, CEA, Fontenay-aux-Roses, France)
  Early acute NK-mediated immunity dictates ability of HSV-1 latent reservoirs to reactivate after early WT challenge
• SP23-63 - Valeria BISIO (INSERM U1342, Institut de Recherche Saint-Louis, Paris, France)
  The Mesenchymal Stromal Cells: A hub for NK immune dysregulation in MDS context

PLENARY SESSIONS

Amphi. Gaston Berger - Level S2Closing Keynote Lecture

Chair: Daniel OLIVE

EFIS-IL Lecture Award

• Fiona POWRIE (University of Oxford, UK)
  Translating Immunology into new Therapies for Inflammatory Bowel Disease

Prize awards & Conclusion