SFI 2025

Foyer - Level S1 Meeting registration

PLENARY SESSIONS

Amphi. Gaston Berger - Level S2Welcome Introduction

• Daniel OLIVE - SFI President

Amphi. Gaston Berger - Level S2Pierre Grabar* Keynote Lecture

* Cofounder and 1^st President of the SFI

Chair: Emmanuelle JOUANGUY (Paris, France)

• Jean-Laurent CASANOVA (Human Genetics of Infectious diseases, Rockefeller University, New York, USA, Imagine institute, Necker Hospital for Sick Children, Paris, France)
  Human genetics of infectious diseases

Amphi. Gaston Berger - Level S2SESSION 1 - Tolerance / Autoimmunity

Chairs: Marianne BURBAGE (Paris, France) & Anne ASTIER (Toulouse, France)

• Carola VINUESA (The Francis Crick Institute, London, UK)
  Title upcoming
• Magali IRLA (Immune tolerance and T cell differentiation, CIML, Marseille, France)
  Thymic Central T Cell Tolerance: From Age-Related Involution to Immune Rejuvenation

Selected short oral presentations

• P1-01 - Meryem ALOULOU (INFINITY, INSERM UMR1291 – CNRS UMR5051 – University of Toulouse, Toulouse, France)
  Follicular Regulatory T Cells: Unexpected Allies of Neuroinflammation
• P1-02 - Claire SOUDAIS (UMR1163, Institut Imagine, Paris, France)
  Inhibition of the CTP synthase 1 prevents GVHD and delays skin graft rejection revealing distinct allo-T-cell responses
• P1-03 - Emeline PAPILLON (U932, Institut Curie, Paris, France)
  How do transposable elements shape T cell thymic selection?

Foyers - Levels S2-S3POSTER SESSION 1 - odd-numbered

Foyer - Level S2E-POSTER SESSION 1

Chair: Fabienne HASPOT (Nantes, France)

See the list of posters presented and the order of presentation

Foyer - Level S2E-POSTER SESSION 2

Chair: Rami BECHARA (Le Kremlin-Bicêtre, France)

See the list of posters presented and the order of presentation

Foyers - Levels S1-S2-S3 Lunch - Coffee - Visit of exhibition & Posters

Salle Louis Armand Ouest - Level S3JOURNÉE FÉDÉRATION D’IMMUNOLOGIE MÉDICALE

Thérapies cellulaires innovantes dans la prévention de la GVH après allogreffe de cellules souches hématopoiétiques

Modérateurs : Stéphanie NGUYEN (Paris, France) & Jean-Hugues DALLE (Paris, France)

• Étienne DAGUINDAU (Besançon, France)
  Physiopathologie de la GVH aigue et prévention en pratique courante
• Mathieu LECLERC (Créteil, France)
  T régulateurs en prévention de la GVH chez l’homme
• Federico SIMONETTA (Genève, Suisse)
  Lymphocytes iNKT murins et modulation des effets GVH/GVL
• Marie-Thérèse RUBIO (Nancy, France)
  Lymphocytes iNKT humains et leur développement clinique dans l’allogreffe de CSH
• Maud D’AVENI-PINEY (Nancy, France)
  Cellules myéloides suppressives (MDSC) dans la greffe de CSH
• Cécile POCHON (Nancy, France)
  Cellules souches stromales mésenchymateuses (CSM) : comment optimiser leur utilisation pour prévenir la GVH ?
• Table ronde

PARALLEL SESSIONS

Salle Louis Armand Est - Level S3SP1 - Germinal Centers Club

Chairs: Carole LE COZ (Toulouse, France) & Céline DELALOY (Rennes, France)

• Pierre MILPIED (Integrative B cell immunology, CIML, Marseille, France)
  Pre-plasma cells proliferate and differentiate at the germinal center-medulla interface of antigen-draining lymph nodes
• Johanne JACOBSEN (Rikshospitalet, University of Oslo, Norway)
  Title upcoming

Selected short oral presentations

• SP1-01 - Yoann MISSOLO (INSERM U1330, Institut Curie, Paris, France)
  CD4+ T Cells Response to Tumor Invasion in Lymph Nodes
• SP1-02 - Emma VALDEVIT (Toulouse institute for infectious and inflammatory diseases, Toulouse, France)
  Human T follicular regulatory cells are composed by two layers of heterogeneity
• SP1-03 - Robert PHILIPPE (Laboratoire Adhesion et Inflammation, INSERM-CNRS-Aix-Marseille Université, Marseille, France)
  Mechanical force resistance rather than affinity as a selection factor driving antibody maturation in secondary lymphoid tissues

Amphi. Gaston Berger - Level S2SP2 - Inborn errors of immunity Club

Chairs: Emmanuel MARTIN (Paris, France) & Tom LE VOYER (Paris, France)

• Vivien BÉZIAT (Human Genetics of Infectious diseases, Imagine institute, Paris, France)
  Genetic Determinants of Severe Cutaneous Oncoviral Infections
• Filomeen HAERYNCK (University of Ghent, Belgium)
  Title upcoming

Selected short oral presentations

• SP2-04 - Jean Sebastien DIANA (Department of Biotherapy, Necker Hospital (APHP), Paris, France)
  Gene therapy for Artemis deficiency: the results of the French ARTEGENE 2 Phase I/II clinical trial
• SP2-05 - Hailun LI (HGID, Institut Imagine, Paris, France)
  Syndromic severe combined immunodeficiency in children with a complete form of inherited JAK1 deficiency
• SP2-06 - Nicolas AYAS (U1151, Institut Necker Enfants Malades, Paris, France)
  A neomorphicIRF4 variant disrupts human Treg biology in Primary Antibody deficiency-associated IBD

Salle 2 - Level S3SP3 - Career development (Young) Club

Chairs: Marie-Astrid BOUTET (Nantes, France) & Joaquin PELLEGRINI (France)

• Julie FLOCH (Association Bernard Gregory (ABG) - Responsable Formation et Accompagnement) & Shahul MOUHAMAD (Miltenyi Biotec - Marketing manager)
  A wide range of opportunities for PhDs
• Paola GARDELLIN (Présidente fondatrice de REVEALIS - Coach professionnel)
  From researcher to entrepreneur: is Women Leadership different from Men’s?
• Renaud POURPRE (Fondateur du collectif Exaltia - Science communicator)
  Tips for becoming a part-time science communicator
• Round-table discussion: Julie FLOCH, Paola GARDELLIN, Renaud POURPRE & Shahul MOUHAMAD

PARALLEL SESSIONS

Amphi. Gaston Berger - Level S2SP4 - Immunometabolism

Chairs: Mehdi BENAMAR (Boston, USA) & Romain RONCAGALLI (Marseille, France)

• Stefanie WCULEK (Institute for Research in Biomedicine, Barcelona, Spain)
  How innate immune cells adapt to environment and function: diverse tales of mitochondria
• Linda SINCLAIR (University of Dundee, UK)
  Fuelling T cells -> Proteostasis in T cells

Selected short oral presentations

• SP4-07 - Axelle PENC (Institut Necker Enfants Malades, Paris, France)
  The innate immune system contributes to the development of Pompe disease and represents an efficient therapeutic target
• SP4-08 - Bastien AZNAR (Institut Necker Enfants-Malades, Paris, France)
  The Histone Demethylase KDM6B Governs the LYVE1+ Perivascular Macrophage Phenotype to Control Adipose Tissue Expandability
• SP4-09 - Margaux SARRET (Sorbonne Université, Inserm U1135, CIMI, Paris, France)
  Age-Dependent Immunometabolism: Energetic Profiles of Lymphocytes and Monocytes

Salle Louis Armand Est - Level S3SP5 - Aging/senescence

Chairs: Bruno LUCAS (Paris, France) & Julie DÉCHANET-MERVILLE (Bordeaux, France)

• Jörg GORONZY (University of Stanford, CA, USA)
  TCF1 and HELIOS – Goddesses of T-cell youth
• María MITTELBRUNN (Centro de Biologia Molecular - UAM, Madrid, Spain)
  Unlocking healthy aging through the immune system

Selected short oral presentations

• SP5-10 - Romain TORRES (INFINITY, INSERM UMR1291, Toulouse, France)
  Aging predisposes naive CD4+ T cell to a pro-inflammatory Th1 fate
• SP5-11 - Bruno MARTIN (Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France)
  IFN-α-driven down-regulation of Foxo1 induces functional remodeling of the peripheral γδ T-cell compartment with Age
• SP5-12 - Manon CHAUVIN (Sorbonne Université, Inserm U1135, CIMI-Paris, Paris, France)
  From Immune Activation to Immune Decline: Neopterin in the Aging Process

Foyers - Levels S1-S2-S3Coffee break - Visit of exhibition - Posters

PARALLEL SESSIONS

Salle Louis Armand Est - Level S3SP6 - Neuroimmunology

Chairs: Nicolas FAZILLEAU (Toulouse, France) & Anne ASTIER (Toulouse, France)

• Marina RUBIO (Physiopathology and Imaging of Neurological Disorders, GIP Cyceron, Normandie University, Caen, France)
  BAMs take the lead: orchestrating neuroinflammation after ischemic stroke
• Mikael SIMONS (Institute of Neuronal Cell Biology, Munich, Germany)
  Myelin pathology & neuroinflammation in the CNS

Selected short oral presentations

• SP6-13 - Mehdi BENAMAR (Division of Immunology, Boston Children’s Hospital, Boston, Massachusetts, USA)
  Notch3+ Regulatory T cells Drive Autoimmune Neuroinflammation in Multiple Sclerosis
• SP6-14 - Irini EVNOUCHIDOU (Centre de Recherche sur l’Inflammation, INSERM U1149, Université Paris Cité, Paris, France)
  A new transcription factor regulating neuroinflammation
• SP6-15 - Nicolas BLANCHARD (Inserm UMR1291 - CNRS UMR5051 - University of Toulouse, Toulouse Institute for Infectious and Inflammatory diseases - Infinity, Toulouse, France)
  Immune evasion by Toxoplasma gondii through epigenetic suppression of neuronal MHC I presentation

Amphi. Gaston Berger - Level S2SP7 - TCR/BCR Signalisation

Chairs: Laurence BATAILLE (Paris, France) & Romain RONCAGALLI (Marseille, France)

• Renaud LESOURNE (Integrative mapping of lymphocyte signaling and function, Toulouse Institute for Infectious and Inflammatory Diseases, Toulouse, France)
  Fine tuning T cell responses through checkpoint regulation and diversification
• Pieta MATTILA (University of Turku, Finland)
  Septin7 regulates the formation of the B cell immune synapse and B cell responses

Selected short oral presentations

• SP7-16 - Hermine FERRAN (U932, Institut Curie, Paris, France)
  The MARK2 kinase acts as a gatekeeper of CD28-dependent co-stimulation in T cells
• SP7-17 - Audrey PAGE (Centre de Recherche en Cancérologie de Lyon (CRCL), Lyon, France)
  Disruption of Intracellular Immune Checkpoints Lowers the Activation Threshold of TCR-T Cells
• SP7-18 - Manuel D. DIAZ-MUNOZ (Inserm U1291, Toulouse Institute for Infectious and Inflammatory Diseases (Infinity), Toulouse, France)
  Post-transcriptional regulation of the B-cell receptor is instrumental for innate B cell maintenance and regulatory function