ERGECD-ITCASS Meeting 2021

Round 2 - Activation of the innate and adaptive immune system

Chairs: Stefan Martin (Freiburg), Marc Vocanson (Lyon) & David Gawkrodger (Sheffield)

Guest lecture

• Cutaneous immune responses to external stimuli
  Kenji Kabashima - Kyoto

Presentations

• 1 - Molecular adaptation of a monocyte cell line to hapten exposure
  Johanna Morot - Lyon

• 2 - Understanding the chemical allergen potency: the role of miRNAs in dendritic cells
  Valentina Galbiati - Milan

• 3 - Understanding the chemical allergen potency: the role of miRNAs in keratinocytes
  Martina Iulini - Milan

• 4 - Dual role of CinA on IL-1b regulation through Nrf2 pathway activation in keratinocytes
  Romain Vallion - Châtenay-Malabry

• 5 - Opposite responses to contact allergens in mice with two common skin protein mutations
  Mia Hamilton Jee - Copenhagen

Questions to speakers

Break

Presentations

• 6 - Feeding of fat-enriched diet causes the loss of resistance to contact hypersensitivity
  Anne-Catherine Rülh-Muth - Freiburg im Breisgau

• 7 - Role of skin microbiome in immunosuppression to contact allergens
  VijayKumar Patra - Lyon

• 8 - Distinct features of metal-specific human CD4+ T cell receptors
  Katherina Siewert - Berlin

• 9 - How T-cells recognize chemicals?
  Marc Pallardy - Châtenay-Malabry

Questions to speakers

Break

Presentations

• 10 - Pathogenic CD8+ epidermis-resident memory T cells displace dendritic epidermal T cells in allergic contact dermatitis
  Anne Sofie Gadsboll - Copenhagen

• 11 - CD8+ epidermal-resident memory T cells recruit neutrophils that are essential for allergen-induced flare-ups in contact dermatitis
  Anders Boutrup Funch - Copenhagen

• 12 - Impact of corticosteroids on the biology of skin resident memory T cells and the recurrence of eczema
  Emi Ono - Lyon

Questions to speakers

Round 3 - Skin sensitization assessment & risk assessment

Chairs: Elena Gimenez-Arnau (Strasbourg), Valentina Galbiati (Milan) & Petra Kern (Strombeek-Bever)

Presentations

• 1 - The kinetic Direct Peptide Reactivity Assay (kDPRA): Intra- and inter-laboratory reproducibility in a seven-laboratory ring trial
  Susanne Kolle - Ludwigshafen

• 2 - The predictivity of the kinetic DPRA (kDPRA) for sensitizer potency assessment
  Andreas Natsch - Vernier

• 3 - Characterization of Nail Acrylates in the kinetic DPRA and consideration of the results for skin sensitization risk assessment
  Carsten Goebel

• 4 - Update on the Bayesian Net Defined Approach
  Petra Kern - Strombeek-Bever

Questions to speakers

Break

Presentations

• 5 - Weight of Evidence Approach for Skin Sensitization Potency Categorization of Fragrance Materials
  Mihwa Na - Woodcliff Lake

• 6 - Development and application of a Next Generation Risk Assessment Framework (NGRA) for the Evaluation of Skin Sensitisation of Cosmetic Ingredients
  Fanny Boislève - Neuilly-Sur-Seine

• 7 - TBD: Next Generation risk assessment: a case study
  Nathalie Alépée - Aulnay-Sous-Bois

• 8 - How to assure consumer safety in skin sensitization without animal testing: demonstration through a case study with resorcinol
  Fleur Tourneix - Aulnay-sous-Bois

Questions to speakers