Webinar EBCnet Forum 2021

Session #3. Plasma cells

Talk participants

Chairs: Claude-Agnès Reynaud & Hans-Martin Jäck

• Dissecting antibody-secreting cells differentiation at single cell level
  Niels J.M. Verstegen (Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands)

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• The Sec22b SNARE is indispensable for plasma cell maintenance and antibody secretion
  Marion Espéli (Université de Paris, Institut de Recherche Saint Louis, EMiLy, Inserm U1160, Paris, France)

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• Single-cell analyses of autoreactive plasma cells from immune thrombocytopenia patients
  Pierre Bruhns (Unit of Antibodies in Therapy and Pathology, Institut Pasteur, UMR 1222 INSERM, Paris, France)

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• TFG controls ER stress, autophagy and plasma cell function
  Dirk Mielenz (Division of Molecular Immunology, Department of Internal Medicine 3, Nikolaus-Fiebiger-Zentrum, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany)

Sponsor - Immudex

• dCODE® Klickmer - Exploring B-cell immunity at the single-cell level
  Valérie Bodemeyer - Immudex

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Break

Session #3 (continued). Plasma cells

Talk participants

Chairs: René E.M. Toes & Idit Shachar

• Metabolic flux analysis of individual antibody-secreting cells – the impact of space, time, and immunization
  Klaus Eyer (Laboratory for Functional Immune Repertoire Analysis, Institute for Pharmaceutical Sciences, D- CHAB, ETH Zürich, Switzerland)

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• Complementary but distinct protective roles of tumor-infiltrating IgG and IgA producing cells
  Yasmine Lounici (Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS 5286, Lyon, France)

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• The BCR acts as a switch between the canonical and non-canonical functions of plasma cells
  Thierry Defrance (Centre International de Recherche en Infectiologie/CIRI, INSERM U1111, Lyon, France)

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• The RNA m6A binding protein YTHDF2 promotes the B cell to plasma cell transition
  Martin Turner (Immunology Programme, The Babraham Institute, Cambridge, CB223AT, UK)

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• IgA production decrease is associated with B cell differentiation and proliferation defects in multiple sclerosis
  Jeremy Morille (Centre de Recherche en Transplantation et Immunologie, INSERM UMR1064, Nantes University, CHU de Nantes, Nantes, France)

Sponsor - Miltenyi Biotec

• SARS-CoV-2 specific B cells and antibodies Analysis by Miltenyi Biotec
  Shahul Mouhamad - Miltenyi Biotec

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Lunch

Session #4. B cells in disease

Talk participants

Chairs: Marion Espéli & Kai-Michael Toellner

• MHCII haplotype determines IgG autoantibody Fc N-glycosylation and development of murine autoimmune skin disease
  Rudolf Armin Manz (Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany)

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• N-linked glycosylation of the immunoglobulin variable domain affects antigen binding and autoreactive B-cell activation
  Theresa Kissel (Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands)

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• Autoantibodies deconvolution in Membranous Nephropathy
  Sara Montagner (Novartis Institutes for BioMedical Research, Basel, Switzerland)

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• B cell defect in Prkcd G510S/G510S mice with autoimmunity and lymphoproliferation
  Marion Moreews (CIRI, Centre International de Recherche en Infectiologie, Univ. Lyon, Inserm, U1111, Université Claude Bernard, Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France)

Sponsor - Stemcell

• Tools for B cell Research
  Graeme Milton - Senior European Market Development Manager, Immunology

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Break

Session #4 (continued). B cells in disease

Talk participants

Chairs: Yolanda R. Carrasco & Jean-Claude Weill

• Transcriptional dysregulation of CVID patients harboring the C104R TNFRSF13B mutation
  Neftali Jose Ramirez (Centre for Chronic Immunodeficiency (CCI), University Medical Centre Freiburg, University of Freiburg, Freiburg, Germany)

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• Inverted direct allorecognition triggers early donor specific antibody response after transplantation
  Xavier Charmetant (CIRI, Centre International de Recherche en Infectiologie, Université de Lyon, INSERM U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France)

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• Post-transcriptional control of neuroinflammation by HuR
  Dunja Capitan-Sobrino (Toulouse Institute for Infectious and Inflammatory Diseases, INSERM (U1291), Toulouse, France)

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• Decreased Levels of T Follicular Helper (CD4+CXCR5+) Cells and CD27+CD38+ and CD27+CD38- B Cells in Ankylosing Spondylitis Patients Correlate with Marker of Inflammation
  Kristina Lejon (Department of Clinical Microbiology, Umeå University, Umeå, Sweden)

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• Follicular helper-like T cells in the lung highlight a novel role of B cells in sarcoidosis
  Laura Bauer (Institute of Immunology, University Hospital Schleswig-Holstein, Kiel, Germany)

Sponsor - Cytek Biosciences

• How spectral flow could be the solution for your lab
  Juliette Desfrançois - Cytek Biosciences