Program Friday 2 July
09:00-10:20
Session #5. Ag recognition/BCR signaling
Talk participants
Chairs: Rudolf Manz & Marieke Van Ham
09:00-09:20
- BCR functions from within the endoplasmic reticulum
Marieta Caganova (Max‐Delbrück‐Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany)
09:20-09:40
- CD20 as a gatekeeper of the resting state of human B cells
Kathrin Kläsener (Biology III, faculty of biology, University Freiburg, Freiburg, Germany)
09:40-10:00
- Tetraspanins: molecular organisers of the B-cell surface
Annemiek van Spriel (Dept. of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands)
10:00-10:20
- Novel players in B cell antigen uptake and trafficking
Dessi Malinova (Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, Ireland)
10:20-10:27
Sponsor - Immudex
dCODE® Klickmer - Exploring B-cell immunity at the single-cell level
Valérie Bodemeyer - Immudex
10:27-10:40
Break
10:40-12:20
Session #6. Genetics of immunoglobulins
Talk participants
Chairs: Ulf Klein & Lars Nitschke
10:40-11:00
- Immunoglobulin enhancers increase RNA polymerase 2 (Pol2) stalling at somatic hypermutation (SHM) target sequences
Jukka Alinikula (Unit of Infections and Immunity, Institute of Biomedicine, University of Turku, Finland)
11:00-11:20
- Study of IgH Locus Suicide Recombination ‘LSR’ in human normal and pathological conditions
Israa Al Jamal (CBRS CRIBL UMR7276 CNRS INSERM1262, Limoges University, Limoges, France)
11:20-11:40
- IgTreeZ: A toolkit for immunoglobulin gene lineage tree analysis
Ramit Mehr (The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel)
11:40-12:00
- A dual effect upon deletion of Special A-T Rich Binding Protein 1 in B cells
Morgane Thomas (Contrôle de la réponse immune B et des Lymphoproliférations, CNRS UMR 7276 Inserm 1062, Limoges, France)
12:00-12:20
- Inactivation of EXO1 nuclease activity on genome maintenance and tumor suppression in Exo1D173A mice in vivo
Richard Chahwan (Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland)