Saturday 23 october 2010
2nd Joint Meeting « Hepatocyte User Group & Medicon Valley Hepatocyte User Forum »
Saturday 23 October 2010
9:00 |
Session 3: |
|---|---|
Cell culture systems: how to accommodate uptake and efflux transport with efficient drug metabolism? |
|
| Chairman: Lassina Badolo | |
| 9:00-9:30 | Interplay of drug metabolism and transport: A real phenomenon or an artifact of the site of measurement? |
| Jashvant Unadkat, University of Washington, Seattle - USA | |
| 9:30-10:00 | ProtoTissue ® : A new functional human 3D liver tissue for in vitro drug testing. |
| Stephen Fey, CEO Drug Mode - Denmark | |
| 10:00-10:30 | Coffee break - Visit of exhibition - Posters |
| 10:30-11:00 | Stability of transporters and cytochrome P450s in hepatocyte culture systems. |
Jacob Kramer Jacobsen, University of Copenhagen, Copenhagen - Denmark |
|
| 11:00-11:30 | An update on metabolism studies using human hepatocytes in primary culture. |
| Maria-José Gomez-Lechon, Hospital La Fe, Valencia - Spain | |
11:30-12:45 |
Oral communications |
| Chairman: Lena Gustavsson | |
| 11:30-11:45 | New in-vitro systems as organ models for hepatic culture |
| Tommaso Sbrana et al., Universita di Pisa, Pisa - Italy | |
| 11:45-12:00 | Hepatic uptake transport in individual versus pooled cryopreserved human hepatocytes |
| Tom De Bruyn et al., Katholieke Universiteit Leuven, Leuven - Belgium | |
| 12:00-12:15 | Medium flow stimutates the expression and activity of detoxication genes in primary human hepatocytes cultured in a multicompartment modular bioreactor |
| Cédric Duret et al., Inserm, Montpellier - France | |
| 12:15-12:30 | Development of a liver microfluidic bioreactor for toxicity and drug metabolism investigations |
| Prot J-M et al., Université de Technologie de Compiègne, Compiègne - France | |
| 12:30-12:45 | A new mitochondrial-based apoptotic test adapted to HepaRG hepatocytes applied to high throughput screening of hepatotoxic compounds using automated imaging analysis |
| K. Pernelle et al., Rennes-1 University, Rennes - France | |
12:45-14:00 |
Lunch - Visit of exhibition - Posters |
14:00-15:00 |
General discussion - Oral communications & posters awards - Closing |
2nd Joint Meeting
