2nd Joint Meeting « Hepatocyte User Group & Medicon Valley Hepatocyte User Forum »

Friday 22 October 2010

8:00-8:30	Registration

8:30-8:40	Welcome and introduction Patrick Maurel

8:40	Session 1:
	Hepatocyte from Stem Cell: where are we, where do we go?
	Chairman: Patrick Maurel
8:40-9:10	Cell reprogramming: extreme cell plasticity
	John De Vos, Inserm Montpellier - France
9:10-9:40	Embryonic and induced pluripotent stem cell derived hepatocytes...
	Nicholas Hannan, University of Cambridge - UK
9:40-10:30	Coffee break - Visit of exhibition - Posters
10:30-11:00	Comparative analysis of hepatocyte-like cells generated from liver progenitor cells and human embryonic stem cells
	Martine Daujat-Chavanieu, Inserm Montpellier - France
11:00-11:30	Hepatic maturation of human fetal hepatocytes in four-compartment 3D perfusion culture
	Toshio Miki, Rangos Research Center, Pittsburgh PA - USA
11:30-12:45	Oral communications
	Chairman: Martin Bayliss
11:30-11:45	Maintenance of hepatic phenotype and function in novel human 3D tissue cultures from reconstituted primary fetal liver tissues
	Cliff Rowe et al., University of Manchester - UK
11:45-12:00	The hepatotrophic growth factor augmenter of liver regeneration (ALR) protects human hepatocytes against induced apoptosis by up-regulation of survival pathways
	Maren Ilowski et al., University of Munich, Munich - Germany
12:00-12:15	System-dependent inhibition of cytochrome P450 (CYP) enzymes
	David B. Buckley et al,. XenoTech LLC, Lenexa KS - USA
12:15-12:30	Optimization of thawing, culture, treatment and enzyme activity determination of cryopreserved human hepatocytes (cryoheps) for their use in the ECVAM international validation study of cytochrome P450 induction
	Alexandre E, et al., KaLy Cell, Strasbourg - France
12:30-12:45	Comparison of different processing times, temperatures and storage methods on RNA stability in human liver
	Serene M.L. Lee et al., University of Munich, Munich - Germany
12:45-14:30	Lunch - Visit of exhibition - Posters
14:30	Session 2:
	miRNAs and siRNAs: Regulating gene expression in hepatocytes
	Chairman: Gabrielle Hawksworth
14:30-15:00	siRNAs to delineate roles of nuclear receptors in induction of Oatps in primary cultures of hepatocytes
	Gabrielle Hawksworth, University of Aberdeen - UK
15:00-15:30	Micro RNA signatures in phenobarbital-induced liver toxicity
	Nigel Gooderham, Imperial College, London - UK
15:30-16:00	Coffee break - Visit of exhibition - Posters
16:00-16:30	AAV-mediated knock-down of apolipoprotein B100 in vivo using SHRNA
	Pavlina Konstantinova, AMT Biopharma, Amsterdam - The Netherlands
16:30-17:00	From plastic to patient: Identifying the barriers to therapeutic oligo delivery
	Steve Hood, GOLD team, PCD DMPK, GSK R&D, Ware - UK
17:00-19:00	Posters session - Wine & Beer Cocktail
19:15	Bus departure for Conference dinner