SFI 2021

Foyers (Levels S1 and S2)Welcome coffee

Microbiota and Mucosal immunity: joint meeting of the SFI and the JSI

Amphi. Gaston Berger (Level S2)

Chairs: Nadine Cerf-Bensussan (Paris) & James di Santo (Paris)

•  Koji Hase (Tokyo, Japan): Maternal gut microbiota in pregnancy influences metabolism
• Gérard Eberl (Paris): Regulation of the immune system and hypothalamus by bacterial muropeptides
•  Kiyoshi Takeda (Osaka, Japan): Bacterial metabolites that mediate the host-microbiota interaction
• Harry Sokol (Paris): Gut Microbiota in inflammatory bowel disease, from description to intervention

Foyers (Levels S2 and S3)Poster Session 2 - even-numbered posters

Foyers (Levels S1 and S2)Coffee break - Visit of exhibition

Amphi. Gaston Berger (Level S2)Microbiota, metabolism and inflammation

Chairs: Valérie Gaboriau-Routhiau (Paris) & Martin Larsen (Paris)

• Benoit Chassaing (Paris): Modern stressors of the host-microbiota interaction in health and diseases
• Marie Bodinier (Nantes): Impact of a maternal supplementation with prebiotic on the microbiota, the immune system and allergy development in offspring

Selected short oral presentations

• Marie-Laure Michel (Jouy-en-Josas): Gut microbiota-derived short-chain fatty acids regulate IL-17 production by mouse and human intestinal γδ T cells
• Bruno Silva-Santos (Lisboa, Portugal): Maternal γδ T cells shape offspring pulmonary type-2 immunity in a microbiota-dependent manner
• Dina Chokr (Paris): Impact of histone lysine demethylase 6B on adipose tissue macrophage plasticity

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Salle Louis Armand Ouest (Level S3)Therapeutic cells Club

Chairs: Eliane Piaggio (Paris) & Makoto Miyara (Paris)

•  Qizhi Tang (San Francisco, USA): Developing antigen-specific regulatory T cell therapy for transplantation and autoimmune diseases
• Sophie Caillat-Zucman (Paris): Mucosal-Associated Invariant T (MAIT) cells: a new source of universal effector cells for allogeneic chimeric antigen receptor (CAR)-therapy

Selected short oral presentations

• Pauline Thomas (Nantes): O-acetylated GD2-CAR modified Vγ9δ2T cells targeting pediatric high-grade gliomas
• Philippe Nicolas (Marseille): Interactomic analyses of primary human T cell activation: a rational basis for the implementation of CAR-T cells
• Geoffrey Guittard (Marseille): Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity

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Salle Louis Armand Est (Level S3)Host-SARS-CoV-2 interactions

Chairs: Anne Hosmalin (Paris) & Frédéric Rieux-Laucat (Paris)

• Darragh Duffy (Paris): Understanding variable immunity to SARS-CoV-2 infection for improved treatment strategies
• Agnès Lehuen (Paris): Role of MAIT cells in the physiopathology of COVID-19

Selected short oral presentations

• Mehdi Benamar (Boston, MA, United States): Treg Cell Notch4 signaling promotes severe lung inflammation in SARS-COV2 infection by limiting amphiregulin-dependent tissue repair
• Nikaïa Smith (Paris): Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection
• Luc de Chaisemartin (Paris): Neutrophil phenotypes and functions are associated with severity and poor prognosis in patients with COVID-19

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Salle 2 (Level S3)Session Médicale - Homéostasie immunitaire au cours de la vie

Modérateurs : Sophie Candon (Rouen) & Delphine Sauce (Paris)

• Victor Appay (Bordeaux): Quantitative and qualitative alterations of the naïve T cell compartment with ageing
• Hélène Vallet (Paris): What is ageing and how immune system can play a role in age-related pathologies

Présentations orales sélectionnées

• Julie Demaret (Lille): Impaired functional T cell response to SARS-CoV-2 after two 2 doses of BNT162b2mRNA vaccine in older people
• Manon Chauvin (Paris): Impact of inflammation on the resilience of the elderly
• Chrystel Marton (Paris): A novel virotherapy encoding human interleukin-7 enhances ex vivo human immune functions in immunosenescent hip fractured trauma patients

Foyers (Levels S1, S2 and S3)Lunch

Coffee - Visit of exhibition - Posters

Amphi. Gaston Berger (Level S2)Imaging the immune system

Chairs: Loredana Saveanu (Paris) & Philippe Bousso (Paris)

• Nicolas Gaudenzio (Toulouse): The neuron-mast cell axis: new perspectives for drug development
• Ana-Maria Lennon-Dumenil (Paris): Gut epithelium colonization by dendritic cells promotes their functional diversification

Selected short oral presentations

• Nicolas Serafini (Paris): Inflammation triggers ILC3 patrolling of the intestinal barrier
• Aïda Meghraoui-Kheddar (Valbonne): High dimensional imaging mass cytometry for the integrative spatial characterization of the Tumor Immune MicroEnvironment from cutaneous squamous cell carcinoma
• Maxime Petit (Paris): Differential regulation of tissue resident macrophages in non-lymphoid organs’ territories

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Salle Louis Armand Ouest (Level S3)Chronic inflammation

Chairs: Sophie Brouard (Nantes) & Renato Monteiro (Paris)

•  Thomas Kamradt (Jena, Germany): Why the joints? Synovial cells translate systemic autoimmunity into joint destruction
• Marc Vocanson (Lyon): Inhibitory checkpoint receptors controlling skin allergy

Selected short oral presentations

• Nicolas Degauque (Nantes): TEMRA CD8⁺ T cells from kidney transplant recipients exhibit enhanced purinergic P2X4 receptor-dependent proinflammatory and migratory responses
• Alice Lepelley (Paris): cGAS-STING-dependent interferon signalling in a mitochondrial disease
• Anaïs Roubertie (Bordeaux): DNase1L3 function in obesity-mediated inflammation and metabolic syndrome

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Salle Louis Armand Est (Level S3)Immunosensing

Chair: Nicolas Manel (Paris)

• Thomas Henry (Lyon): Pyrin inflammasome: from bacterial infections to autoinflammatory diseases
•  Nadine Laguette (Montpellier): STING orchestrates the crosstalk between polyunsaturated fatty acids metabolism and inflammatory responses

Selected short oral presentations

• Clara Taffoni (Montpellier): The cooperation between the cGAS-STING and DNA-PK pathways shapes cancer-related inflammation
• Nadia Jeremiah (Paris): A RELA rheostat tunes innate-like antiviral response in T cells
• Bakhos Jneid (Paris): cGAMP-loaded Virus-Liked Particles (cGAMP-VLP) elicit STING-dependent anti-tumor immune responses

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Salle 2 (Level S3)Session Médicale - Immunologie de l’allergie

Modérateurs : Joana Vitte (Marseille) & Laurent Reber (Toulouse)

• Camille Audousset (Lille): The role of NOD1 in the innate immunity and allergic sensitization in the lung: from pathophysiology to therapeutic perspectives
• Michel Arock (Paris): Tryptase in all its states: from allergy to mastocytosis

Présentations orales sélectionnées

• Marine-Alexia Lefevre (Lyon): Unique molecular signatures typify skin inflammation induced by chemical allergens and irritants
• Pauline Loos (Liège, Belgium): Persistent gammaherpesvirus infection reprograms the alveolar macrophage niche for the long-term by dampening type 2 properties of group 2 innate lymphoid cells
• Laurent Delpy (Limoges): Targeting IgE polyadenylation signal with antisense oligonucleotides decreases IgE secretion and plasma cell viability

Amphi. Gaston Berger (Level S2)Infection and inflammation: focus on SARS-CoV-2

Chairs: Abdel Saoudi (Toulouse) & Véronique Witko (Paris)

• Sarah Walmsley (Edinburgh, UK): Inflammation and hypoxia
• Leif Sander (Berlin, Germany): Innate immunity and response to vaccins
• Frédéric Rieux-Laucat (Paris): Too much or too little cytokines in the SARS-Cov2 infection: lessons from genetic diseases on pathophysiological mechanisms

Foyers (Levels S1, S2 and S3)Coffee break - Visit of exhibition - Posters

Amphi. Gaston Berger (Level S2)New anti-viral vaccine strategies: the example of SARS-CoV-2

Chairs: Claude Leclerc (Paris) & Béhazine Combadière (Paris)

• Dan Barouch (Boston, USA): TBD
• Hugo Mouquet (Paris): Potent human broadly neutralizing SARS-CoV-2 antibodies

Amphi. Gaston Berger (Level S2)Keynote lecture

Chair: Renato Monteiro (Paris)

• Max Cooper (Atlanta, USA): How did our immune system evolve?

Congress Dinner