SFI 2021

Foyers (Levels S1 and S2)Welcome coffee

Amphi. Gaston Berger (Level S2)Cancer immunology: joint meeting of the SFI and the BSI

Chairs: Jacques Nunès (Marseilles) & Karin Tarte (Rennes)

•  Caetano Reis e Sousa (London, UK): DaNGeRous indigestion and immunity to cancer
•  Awen Gallimore (Cardif, UK): T cell-driven remodelling of the tumour microenvironment promotes tumour immunity
• Sebastien Amigorena (Paris): Epigenetic re-programing of CAR-T cells Suv39h1 ablation
• Karin Tarte (Rennes): Stromal cells as the key component of Follicular Lymphoma microenvironment

Foyers (Levels S1, S2 and S3)Coffee break - Visit of exhibition - Posters

Salle 2 (Level S3)Vaccination - Qu’est-ce que la COVID nous a apporté ?

Modérateurs : Guislaine Carcelain (Paris) & Jean-Daniel Lelièvre (Créteil)

Programme préliminaire

• COVID19 vaccine: what have we learned or rediscovered
  Jean-Daniel Lelièvre (Créteil)

• Réponse immunitaire vaccinale
  • Anne-Sophie Beignon (Fontenay-aux-Roses): Vaccine-induced long-term innate immunological imprinting
  • Matthieu Mahevas (Créteil): mRNA vaccination of naive and COVID-19-recovered individuals elicits potent memory B cells that recognize SARS-CoV-2 variants

• Discussion

• Quels vaccins et comment les utiliser ?
  • Brigitte Autran (Paris) : Nouvelles plateformes vaccinales
  •  Guiseppe Pantaleo (Lausanne, Suisse): Kinetics of humoral responses following vaccination with mRNA vaccine

• Discussion

• Table ronde - Comment bien vacciner nos patients ? : immunodéprimés, personnes âgées
  Anne Conrad (Lyon), Olivier Epaulard (Grenoble) et Stéphane Paul (Saint-Étienne)

Amphi. Gaston Berger (Level S2)Regulation of inflammatory responses

Chairs Véronique Witko (Paris)

• Marco Cassatella (Verona, Italy): Advances on slan⁺-monocytes and monocyte-derived slan⁺-cells
• Nicolas Fazilleau (Toulouse): Regulatory T cells promote T follicular helper cell commitment by modifying dendritic cell polarizing capacities

Selected short oral presentations

Saniya Kari (Toulouse): Differential effects of Vitamin D on the migration of effector and regulatory T cells across the blood-brain barrier

Dyhia Melbouci (Bobigny): Neutrophil extracellular traps trigger an enhanced pro-inflammatory response in macrophage subpopulations in rheumatoid arthritis patients

Cédric Jacqueline (Nantes): Local microenvironment finely shapes the fate of inflammatory monocytes after severe lung inflammation

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Salle Louis Armand Ouest (Level S3)Immuno-microbial interactions at mucosal sites

Chairs: Delphine Sterlin (Paris) & Guy Gorochov (Paris)

• Stéphane Paul (Saint-Étienne): Role of mucosal IgA in inflammatory bowel disease
• Delphine Sterlin (Paris): Human IgA coat a wide range of gut commensals

Selected short oral presentations

• Caroline Plazy (Grenoble): Immuno-Metabolite discovery: study of metabolic adaptation of Pseudomonas aeruginosa in Cystic Fibrosis (CF) patients
• Aubin Pitiot (Tours): Mucosal administration of anti-bacterial antibody provides long-term protection against Pseudomonas aeruginosa respiratory infection
• Adelaide Gelineau (Bonn, Germany): Dietary fiber-mediated improvement of glucose tolerance requires type 2 conventional dendritic cells in mice fed a high-fat diet

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Salle Louis Armand Est (Level S3)Receptors and immunity

Chairs: Marion Espeli (Paris) & Renato Monteiro (Paris)

• Loredana Saveanu (Paris): Endosomal signaling of antigen receptors
• Marion Espeli (Paris): Hematological disorder associated Cxcr4-gain-of-function mutation leads to uncontrolled extrafollicular immune response

Selected short oral presentations

• Alba De Juan (Paris): Fine-tuning of IL-4-induced immune responses by Aryl Hydrocarbon Receptor
• Alice Lavanant (Strasbourg): CD169⁺ macrophages in lymph node and spleen critically depend on dual RANK and LTβR signaling
• Arantxa Agesta (Toulouse): Role of the transcriptional regulator Eomes in shaping T cell response to 4-1BB agonist immunotherapy

Foyers (Levels S1, S2 and S3)Lunch

Coffee - Visit of exhibition - Posters

Salle Louis Armand Ouest (Level S3)B cells

Chairs: Michel Cogné (Limoges) & Patricia Amé (Rennes)

• Michel Cogné (Limoges): A new IgG5 antibody
• Michela Di Virgilio (Berlin, Germany): Temporal control of individual steps in Igh Switching: dissecting the TGFβ-mediated regulation of IgA Class Switch recombination

Selected short oral presentations

• Michel Cogné (Limoges): mRNA and DNA high throughput sequencing reveals major alterations in the immunoglobulin repertoire landscape in severe COVID-19 patients
• Dunja Capitán Sobrino (Toulouse): The RNA-binding protein HuR controls innate B cell responses and neuroinflammation
• Viviana Valeri (Paris): Mouse memory B cell subsets and recall responses

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Salle Louis Armand Est (Level S3)Dendritic cells

Chairs: Anne Hosmalin (Paris) & Elena Tomasello (Marseille)

• Elena Tomasello (Marseille): Novel insights in the dynamics and role of plasmacytoid dendritic cell activity during viral infections
• Pierre Guermonprez (London, UK; Paris): Role of dendritic cells in lung cancer

Selected short oral presentations

• Claire Murat (Toulouse): Effect of the tumor environment on the programming of locally generated conventional dendritic cells
• Véronique Godot (Créteil): CD40-targeting vaccination induces SARS-CoV 2 spike-specific human B and T cells with a long-term memory phenotype in a humanized mice model
• Javiera Villar (Paris): ETV3 and ETV6 enable monocyte differentiation into dendritic cells during inflammation by repressing interferon-stimulated genes

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Amphi. Gaston Berger (Level S2)Single cell approaches to analyse immune cells

Chairs: Laurence Bataille (Paris) & Vassili Soumelis (Paris)

• Mickael Menager (Paris): A monocyte/dendritic cell molecular signature of SARS-CoV-2-related multisystem inflammatory syndrome in children (MIS-C) with severe myocarditis
• Muzlifah Haniffa (Newcastle, UK): Decoding the developing human immune system

Selected short oral presentations

• Anne-Sophie Chretien (Marseille): High-dimensional mass cytometry analysis of NK cell alterations in AML identifies a subgroup with adverse clinical outcome
• Jason Cosgrove (Paris): Metabolic heterogeneity in hematopoietic progenitors fuels innate immunity
• Eoghann White (Bordeaux): Evidence of rejuvenated HIV-1-specific CD8⁺ T cells after 30 years of treated infection

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Salle 2 (Level S3)Session Médicale - Interleukin-17 : rôle dans l’inflammation et l’infection

Modérateurs : Jean-François Nicolas (Lyon) & Barbara Seitz-Polski (Nice)

• Pierre Miossec (Lyon): IL-17 from discovery to targeting
• Anne Puel (Paris): Inborn errors of human IL-17 immunity

Présentations orales sélectionnées

• Barbara Seitz-Polski (Nice): Baseline and early functional immune response is associated with subsequent clinical outcomes of PD-1 inhibition therapy in metastatic melanoma patients
• Julien Marie (Lyon): TGF-ß signaling ensures stability of the genetic program of already differentiated T_H17 cells preventing from inflammation-induced cancer
• Rami Bechara (Pittsburgh, USA): RNA m6A methylation guides IL-17-driven autoimmunity through IMP2-dependent regulation of C/EBP transcription factors

Amphi. Gaston Berger (Level S2)Allergy

Chairs: Olivier Boyer (Rouen) & Gérard Eberl (Paris)

• Bart N. Lambrecht (Gent, Belgium): TBD
• Cathryn Nagler (Chicago, USA): Regulation of allergic responses to food by intestinal bacteria

Amphi. Gaston Berger (Level S2)Keynote lecture

Chair: Hans Yssel (Paris)

• Daniel Olive (Marseille): Butyrophilins and Vγ9Vδ2 from milk fat to immunoregulation in humans and patient treatment

Amphi. Gaston Berger (Level S2)Prize awards - Conclusion