SFI 2021

7 to 9 December 2021 - Cité des sciences et de l’industrie, Paris, France

Bandeau - SFI 2021

Thursday 9 December


Foyers (Levels S1 and S2)Welcome coffee

Plenary Session


Amphi. Gaston Berger (Level S2)Cancer immunology: joint meeting of the SFI and the BSI

Logo LabEx-IGOLogo BSIChairs: Jacques Nunès (Marseilles) & Karin Tarte (Rennes)

  •  Caetano Reis e Sousa (London, UK): DaNGeRous indigestion and immunity to cancer
  •  Awen Gallimore (Cardif, UK): T cell-driven remodelling of the tumour microenvironment promotes tumour immunity
  • Sebastien Amigorena (Paris): Epigenetic re-programing of CAR-T cells Suv39h1 ablation
  • Karin Tarte (Rennes): Stromal cells as the key component of Follicular Lymphoma microenvironment


Foyers (Levels S1, S2 and S3)Coffee break - Visit of exhibition - Posters

Journée de la Fédération d’Immunologie Médicale


Salle 2 (Level S3)Vaccination - Qu’est-ce que la COVID nous a apporté ?

Modérateurs : Guislaine Carcelain (Paris) & Jean-Daniel Lelièvre (Créteil)

Programme préliminaire

  • COVID19 vaccine: what have we learned or rediscovered
    Jean-Daniel Lelièvre (Créteil)
  • Réponse immunitaire vaccinale
    • Anne-Sophie Beignon (Fontenay-aux-Roses): Vaccine-induced long-term innate immunological imprinting
    • Matthieu Mahevas (Créteil): mRNA vaccination of naive and COVID-19-recovered individuals elicits potent memory B cells that recognize SARS-CoV-2 variants
  • Discussion
  • Quels vaccins et comment les utiliser ?
    • Brigitte Autran (Paris) : Nouvelles plateformes vaccinales
    •  Guiseppe Pantaleo (Lausanne, Suisse): Kinetics of humoral responses following vaccination with mRNA vaccine
  • Discussion
  • Table ronde - Comment bien vacciner nos patients ? : immunodéprimés, personnes âgées
    Anne Conrad (Lyon), Olivier Epaulard (Grenoble) et Stéphane Paul (Saint-Étienne)

Parallel Sessions


Amphi. Gaston Berger (Level S2)Regulation of inflammatory responses

Chairs Véronique Witko (Paris)

  • Marco Cassatella (Verona, Italy): Advances on slan+-monocytes and monocyte-derived slan+-cells
  • Nicolas Fazilleau (Toulouse): Regulatory T cells promote T follicular helper cell commitment by modifying dendritic cell polarizing capacities

Selected short oral presentations

  • Saniya Kari (Toulouse): Differential effects of Vitamin D on the migration of effector and regulatory T cells across the blood-brain barrier
  • Dyhia Melbouci (Bobigny): Neutrophil extracellular traps trigger an enhanced pro-inflammatory response in macrophage subpopulations in rheumatoid arthritis patients
  • Cédric Jacqueline (Nantes): Local microenvironment finely shapes the fate of inflammatory monocytes after severe lung inflammation

  • 11:15-12:45

    Salle Louis Armand Ouest (Level S3)Immuno-microbial interactions at mucosal sites

    Chairs: Delphine Sterlin (Paris) & Guy Gorochov (Paris)

    • Stéphane Paul (Saint-Étienne): Role of mucosal IgA in inflammatory bowel disease
    • Delphine Sterlin (Paris): Human IgA coat a wide range of gut commensals

    Selected short oral presentations

    • Caroline Plazy (Grenoble): Immuno-Metabolite discovery: study of metabolic adaptation of Pseudomonas aeruginosa in Cystic Fibrosis (CF) patients
    • Aubin Pitiot (Tours): Mucosal administration of anti-bacterial antibody provides long-term protection against Pseudomonas aeruginosa respiratory infection
    • Adelaide Gelineau (Bonn, Germany): Dietary fiber-mediated improvement of glucose tolerance requires type 2 conventional dendritic cells in mice fed a high-fat diet


    Salle Louis Armand Est (Level S3)Receptors and immunity

    Chairs: Marion Espeli (Paris) & Renato Monteiro (Paris)

    • Loredana Saveanu (Paris): Endosomal signaling of antigen receptors
    • Marion Espeli (Paris): Hematological disorder associated Cxcr4-gain-of-function mutation leads to uncontrolled extrafollicular immune response

    Selected short oral presentations

    • Alba De Juan (Paris): Fine-tuning of IL-4-induced immune responses by Aryl Hydrocarbon Receptor
    • Alice Lavanant (Strasbourg): CD169+ macrophages in lymph node and spleen critically depend on dual RANK and LTβR signaling
    • Arantxa Agesta (Toulouse): Role of the transcriptional regulator Eomes in shaping T cell response to 4-1BB agonist immunotherapy


    Foyers (Levels S1, S2 and S3)Lunch

    Coffee - Visit of exhibition - Posters

    Parallel Sessions


    Salle Louis Armand Ouest (Level S3)B cells

    Chairs: Michel Cogné (Limoges) & Patricia Amé (Rennes)

    • Michel Cogné (Limoges): A new IgG5 antibody
    • Michela Di Virgilio (Berlin, Germany): Temporal control of individual steps in Igh Switching: dissecting the TGFβ-mediated regulation of IgA Class Switch recombination

    Selected short oral presentations

    • Michel Cogné (Limoges): mRNA and DNA high throughput sequencing reveals major alterations in the immunoglobulin repertoire landscape in severe COVID-19 patients
    • Dunja Capitán Sobrino (Toulouse): The RNA-binding protein HuR controls innate B cell responses and neuroinflammation
    • Viviana Valeri (Paris): Mouse memory B cell subsets and recall responses


    Salle Louis Armand Est (Level S3)Dendritic cells

    Chairs: Anne Hosmalin (Paris) & Elena Tomasello (Marseille)

    • Elena Tomasello (Marseille): Novel insights in the dynamics and role of plasmacytoid dendritic cell activity during viral infections
    • Pierre Guermonprez (London, UK; Paris): Role of dendritic cells in lung cancer

    Selected short oral presentations

    • Claire Murat (Toulouse): Effect of the tumor environment on the programming of locally generated conventional dendritic cells
    • Véronique Godot (Créteil): CD40-targeting vaccination induces SARS-CoV 2 spike-specific human B and T cells with a long-term memory phenotype in a humanized mice model
    • Javiera Villar (Paris): ETV3 and ETV6 enable monocyte differentiation into dendritic cells during inflammation by repressing interferon-stimulated genes


    Amphi. Gaston Berger (Level S2)Single cell approaches to analyse immune cells

    Logo 10X-GenomicsChairs: Laurence Bataille (Paris) & Vassili Soumelis (Paris)

    • Mickael Menager (Paris): A monocyte/dendritic cell molecular signature of SARS-CoV-2-related multisystem inflammatory syndrome in children (MIS-C) with severe myocarditis
    • Muzlifah Haniffa (Newcastle, UK): Decoding the developing human immune system

    Selected short oral presentations

    • Anne-Sophie Chretien (Marseille): High-dimensional mass cytometry analysis of NK cell alterations in AML identifies a subgroup with adverse clinical outcome
    • Jason Cosgrove (Paris): Metabolic heterogeneity in hematopoietic progenitors fuels innate immunity
    • Eoghann White (Bordeaux): Evidence of rejuvenated HIV-1-specific CD8+ T cells after 30 years of treated infection


    Salle 2 (Level S3)Session Médicale - Interleukin-17 : rôle dans l’inflammation et l’infection

    Logo UCBModérateurs : Jean-François Nicolas (Lyon) & Barbara Seitz-Polski (Nice)

    • Pierre Miossec (Lyon): IL-17 from discovery to targeting
    • Anne Puel (Paris): Inborn errors of human IL-17 immunity

    Présentations orales sélectionnées

    • Barbara Seitz-Polski (Nice): Baseline and early functional immune response is associated with subsequent clinical outcomes of PD-1 inhibition therapy in metastatic melanoma patients
    • Julien Marie (Lyon): TGF-ß signaling ensures stability of the genetic program of already differentiated TH17 cells preventing from inflammation-induced cancer
    • Rami Bechara (Pittsburgh, USA): RNA m6A methylation guides IL-17-driven autoimmunity through IMP2-dependent regulation of C/EBP transcription factors

    Plenary Sessions


    Amphi. Gaston Berger (Level S2)Allergy

    Chairs: Olivier Boyer (Rouen) & Gérard Eberl (Paris)

    • Bart N. Lambrecht (Gent, Belgium): TBD
    • Cathryn Nagler (Chicago, USA): Regulation of allergic responses to food by intestinal bacteria


    Amphi. Gaston Berger (Level S2)Keynote lecture

    Chair: Hans Yssel (Paris)

    • Daniel Olive (Marseille): Butyrophilins and Vγ9Vδ2 from milk fat to immunoregulation in humans and patient treatment


    Amphi. Gaston Berger (Level S2)Prize awards - Conclusion